Immediate and delayed hypersensitivity reactions to a single dose of oxaliplatin.
نویسندگان
چکیده
منابع مشابه
Successful rechallenge for oxaliplatin hypersensitivity reactions in patients with metastatic colorectal cancer.
BACKGROUND Discontinuation of oxaliplatin-containing regimens is sometimes necessary due to hypersensitivity reactions for which effective countermeasures have not yet been identified. PATIENTS AND METHODS We retrospectively reviewed cases in which hypersensitivity reactions developed in 623 patients treated with oxaliplatin for colorectal cancer. Clinical outcomes of patients who underwent o...
متن کاملHypersensitivity reactions to oxaliplatin: clinical features and risk factors in Koreans.
BACKGROUND AND AIM Oxaliplatin hypersensitivity is a well-known adverse reaction but the prevalence varies and data for frequency and clinical features have not been reported for Korea. Here we evaluates the prevalence and risk factors for hypersensitivity reactions to oxaliplatin after chemotherapy. METHODS Clinical information on all patients treated with oxaliplatin was retrospectively rev...
متن کاملSerious delayed hypersensitivity reaction to oxaliplatin.
With great interest we read the articles of Siu et al. [1] and Maindrault-Goebel et al. [2]. Both report on immediate type hypersensitivity reactions to oxaliplatin, occurring in about 10–15% of patients, mostly after several courses of therapy. We recently observed a quite different presentation of hypersensitivity to oxaliplatin, consisting of severe respiratory symptoms about 24 h after the ...
متن کاملOral tolerance for delayed type hypersensitivity contribution of local and peripheral mechanisms
Oral tolerance is a physiological immune mechanism, which controls the outcome of deleterious hypersensitivity reactions to environmental antigens absorbed through the gastrointestinal tract, and maintains homeostasis. Using a mouse model of oral tolerance of delayed type hypersensitivity to contact allergens, i.e. haptens, we have examined the mechanisms involved in the induction of oral toler...
متن کاملA New Practical Desensitization Protocol for Oxaliplatin-Induced Immediate Hypersensitivity Reactions: A Necessary and Useful Approach.
BACKGROUND AND OBJECTIVE Desensitization protocols for patients with immediate hypersensitivity reactions (IHSRs) have proven to be effective, but they are not widely used in clinical practice because of impracticalities such as high cost, long procedure duration, and a lack of trained personnel. We aimed to determine the clinical characteristics of oxaliplatin-induced IHSRs and assess measures...
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ورودعنوان ژورنال:
- Clinical colorectal cancer
دوره 14 2 شماره
صفحات -
تاریخ انتشار 2015